反応 #167238

反応方程式

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-bromo-5-fluoro-3-methyl-benzo[b]thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

収率 60.5%

1-(5-Fluoro-3-methyl-benzo[b]thiophen-2-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

収率 60.5%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他to afford the crude product
2. 2
   その他Purification by column chromatography on silica gel (1% MeOH in chloroform)

実験手順

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 79.79 mg, 0.4508 mmol) was reacted with 2-bromo-5-fluoro-3-methyl-benzo[b]thiophene (110 mg, 0.4508 mmol), 1,4-dioxane (5 mL), copper iodide (8.58 mg, 0.04508 mmol), trans-1,2-diamino cyclohexane (15.48 mg, 0.1352 mmol) and potassium carbonate (124.6 mg, 0.9016 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in chloroform) afforded 84 mg of the product (60.45% yield).

出典