反応 #167206

反応方程式

1-pyridin-3-yl-imidazolidin-2-one

5-bromo-1-ethyl-1H-indole

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

収率 49.3%

1-(1-Ethyl-1H-indol-5-yl)-3-pyridin-3-yl-imidazolidin-2-one

収率 49.3%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他to afford the crude product
2. 2
   その他Purification by column chromatography on silica gel (30% ethylacetate in hexane)

実験手順

Using the same reaction conditions as in Example 1, 1-pyridin-3-yl-imidazolidin-2-one (I-1b: 200 mg, 1.226 mmol) was reacted with 5-bromo-1-ethyl-1H-indole (274 mg, 1.226 mmol), 1,4-dioxane (10 mL), copper iodide (23.3 mg, 0.1226 mmol), trans-1,2-diamino cyclohexane (20.99 mg, 1.839 mmol) and potassium carbonate (338 mg, 2.452 mmol) to afford the crude product. Purification by column chromatography on silica gel (30% ethylacetate in hexane), afforded 185 mg of the product (49.33% yield).

出典