反応 #1667052

反応方程式

1-pyrrolidino-1-cyclohexene

m-trifluoromethylphenacyl bromide

water

toluene

→

2-(m-Trifluoromethylphenacyl)cyclohexanone

反応条件

後処理

1. 1
   workup.ADDITIONA stirred mixture of 15.9 g
2. 2
   温度under reflux for 2 hours
3. 3
   温度refluxed for 2 hours
4. 4
   その他The layers were separated
5. 5
   その他the organic phase was dried
6. 6
   濃縮concentrated to 25 g
7. 7
   workup.DISTILLATIONDistillation
8. 8
   その他provided 12.0 g

実験手順

A stirred mixture of 15.9 g. (0.11 mole) of 1-pyrrolidino-1-cyclohexene, 28.0 g. (0.11 mole) of m-trifluoromethylphenacyl bromide, and 100 ml. of toluene was heated under reflux for 2 hours, diluted with water and refluxed for 2 hours. The layers were separated, and the organic phase was dried and concentrated to 25 g. of liquid. Distillation provided 12.0 g. (42%) of liquid, b.p. 137°-138° (0.075 mm.).

出典