反応 #166573

反応方程式

hydrogen chloride

ethyl 7-(2-(4-isopropylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxylate

lithium hydroxide hydrate

→

product

収率 101.6%

lithium 7-(2-(4-isopropylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxylate

収率 101.6%

溶媒

H2O

反応条件

後処理

1. 1
   温度The mixture was cooled to ambient temperature
2. 2
   その他The H2O was removed under reduced pressure
3. 3
   workup.WAITthe residue placed under high vacuum for 16 hours

実験手順

To ethyl 7-(2-(4-isopropylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxylate (5.68 g, 15.8 mmol) in H2O (30 mL) was added lithium hydroxide hydrate (0.67 g, 16.0 mmol). The reaction mixture was heated to 95° C. for 4 hours. The mixture was cooled to ambient temperature and hydrogen chloride (0.0394 mL, 4M in dioxane) was added. The mixture was stirred for 10 minutes. The H2O was removed under reduced pressure and the residue placed under high vacuum for 16 hours to give the product (5.43 g).

出典