反応 #165930

反応方程式

Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

Sodium sulphite

→

Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

収率 91.4%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他Reaction mass
2. 2
   その他Organic and aqueous layer separated dichloromethane layer
3. 3
   洗浄was washed with water (2×200 ml)
4. 4
   濃縮Dichloromethane layer was then concentrated to residue

実験手順

Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (100 g) dissolved in dichloromethane (500 ml). Sodium sulphite solution (15%, 1000 ml) was added to it. Reaction mass was stirred for 8 hrs. Organic and aqueous layer separated dichloromethane layer was washed with water (2×200 ml). Dichloromethane layer was then concentrated to residue to get Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 67 g)

出典