反応 #165929

反応方程式

Ethyl-2-(3-bromo-2-methoxytetrahydrofuran-3-yl)-2-oxoacetate

Triethyl amine

Hydrogen

→

Ethyl-2-(2-methoxytetrahydrofuran-3-yl)-2-oxoacetate

収率 98.1%

溶媒

Ethanol

反応条件

後処理

1. 1
   その他reaction
2. 2
   その他Reaction mass
3. 3
   ろ過was filtered through hyflow
4. 4
   濃縮concentrated to residue
5. 5
   ろ過filtered
6. 6
   その他to remove triethylamine HBr salt
7. 7
   濃縮Filtrate was concentrated

実験手順

Ethyl-2-(3-bromo-2-methoxytetrahydrofuran-3-yl)-2-oxoacetate (8.5 g) was dissolved in Ethanol (85 ml). Triethyl amine (3.66 g) was added to the reaction mass. 5% Palladium on Carbon (0.85 g) was added and reaction was hydrogenated at 4-5 kg pressure of Hydrogen for 8 hrs. Reaction mass was filtered through hyflow and concentrated to residue. This residue was slurried in methyltert-butylether (42 ml) and filtered to remove triethylamine HBr salt. Filtrate was concentrated to get oily residue of Ethyl-2-(2-methoxytetrahydrofuran-3-yl)-2-oxoacetate (yield 6.0 g).

出典