反応 #165928

反応方程式

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate

Ethanol

N-bromosuccinimide

→

Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他reaction mass
2. 2
   温度by maintaining temp below 10° C
3. 3
   その他Reaction mass
4. 4
   その他Reaction mass
5. 5
   洗浄was washed with sodium bicarbonate solution (8%, 3×400 ml)
6. 6
   その他Reaction mass
7. 7
   濃縮was then concentrated to residue

実験手順

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (100 g) was dissolved in dichloromethane (500 ml) and Ethanol (150 ml) was added to reaction mass and then reaction mass was cooled to 5 to 10° C. N-bromosuccinimide (115 g) was added lot wise by maintaining temp below 10° C. Reaction mass was then stirred at 20-30° C. till completion of reaction. Reaction mass was washed with sodium bicarbonate solution (8%, 3×400 ml). Reaction mass was then concentrated to residue to get Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 170 g).

出典