反応 #165884

反応方程式

phenyl 2-hydroxy-4,5-dimethoxybenzoate

methyl 2-amino-1,3-thiazole-4-carboxylate

methanol

→

same compound ( 5a )

収率 55.2%

2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester

収率 55.2%

溶媒

xylene

反応条件

後処理

1. 1
   温度was then heated
2. 2
   温度After cooling
3. 3
   ろ過The precipitated crystal was collected by filtration
4. 4
   その他dried under reduced pressure at 60° C.

実験手順

In 250 mg of xylene were suspended 250 mg of phenyl 2-hydroxy-4,5-dimethoxybenzoate (3a) and 144 mg of methyl 2-amino-1,3-thiazole-4-carboxylate (4a) in a stream of argon, which was then heated to reflux (at 140° C.) for 7 hours. The reaction was not completed. After cooling, methanol was added, followed by stirring for one hour. The precipitated crystal was collected by filtration and dried under reduced pressure at 60° C. to provide 170 mg of the same compound (5a) as that of Example 4 at a yield of 55%.

出典