反応 #165751

反応方程式

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

収率 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

収率 70.0%

溶媒

DCM

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   その他the solvent was removed in vacuo
3. 3
   その他the residue triturated with MeOH
4. 4
   ろ過The resultant filtrate was filtered off

実験手順

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

出典