反応 #165056

反応方程式

(3-phenoxy-phenyl)-methanol

triphenylphosphine

carbon tetrachloride

→

title compound

収率 94.0%

1-Chloromethyl-3-phenoxy-benzene

収率 94.0%

反応条件

後処理

1. 1
   温度under reflux
2. 2
   濃縮concentrated under a reduced pressure
3. 3
   その他The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1)

実験手順

To a solution of (3-phenoxy-phenyl)-methanol (2.00 g, 10.0 mmol) in carbon tetrachloride (40 mL) was added triphenylphosphine (3.15 g, 12.0 mmol) at room temperature. The reaction solution was stirred under nitrogen atmosphere for 5 hours and 40 minutes under reflux. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (2.05 g, 94%).

出典