反応 #165042

反応方程式

(4-(pyridin-2-yloxymethyl)-phenyl)methanol

triphenylphosphine

carbon tetrachloride

→

title compound

収率 51.1%

2-(4-Chloromethyl-benzyloxy)-pyridine

収率 51.1%

反応条件

後処理

1. 1
   温度under reflux for 2 hours and 10 minutes
2. 2
   濃縮concentrated under a reduced pressure
3. 3
   その他The residue was purified by silica gel column chromatography (heptane: acetic acid=8:1)

実験手順

A mixture of (4-(pyridin-2-yloxymethyl)-phenyl)methanol (540 mg, 2.51 mmol) described in Manufacturing Example 2-1-1, triphenylphosphine (856 mg, 3.27 mmol) and carbon tetrachloride (10.8 g, 10.2 mmol) was stirred under reflux for 2 hours and 10 minutes. The reaction solution was cooled to room temperature, and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane: acetic acid=8:1) to obtain the title compound (300 mg, 51.1%).

出典