反応 #164982

反応方程式

(4-(pyridin-2-yloxymethyl)-phenyl)methanol

→

title compound

収率 42.0%

4-(Pyridin-2-yloxymethyl)-benzaldehyde

収率 42.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered through a Celite pad
2. 2
   その他the solvent was evaporated under a reduced pressure
3. 3
   その他The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4)

実験手順

To a mixture of (4-(pyridin-2-yloxymethyl)-phenyl)methanol (1.9 g, 8.6 mmol) described in Manufacturing Example 2-1-1 and methylene chloride (30 mL) was added manganese dioxide (15 g, 17 mmol) at room temperature, which was stirred overnight at that temperature. The reaction mixture was filtered through a Celite pad, and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4) to obtain the title compound (770 mg, 42%).

出典