反応 #164981

反応方程式

sodium hydride

1,4-benzenedimethanol

2-fluoropyridine

N,N-dimethylformamide

→

title compound

収率 67.9%

(4-(Pyridin-2-yloxymethyl)-phenyl)methanol

収率 67.9%

溶媒

Water

反応条件

後処理

1. 1
   抽出was then extracted with ethyl acetate
2. 2
   洗浄The organic layer was washed with saturated aqueous sodium chloride
3. 3
   その他the solvent was evaporated under a reduced pressure
4. 4
   その他The residue was purified by NH silica gel column chromatography (ethyl acetate:heptane=1:1)

実験手順

To a mixture of 1,4-benzenedimethanol (5.5 g, 40 mmol), 2-fluoropyridine (1.3 g, 13 mmol) and N,N-dimethylformamide (15 mL) was added sodium hydride (1.4 g, 40 mmol, 66% in oil) at 0° C., which was stirred for 20 minutes at room temperature and for 1 hour at 70° C. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, and the solvent was evaporated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate:heptane=1:1) to obtain the title compound (1.9 g, 66%).

出典