反応 #164865

反応方程式

Benzaldehyde

benzaldehyde

4-Acetylbenzonitrile

sodium hydroxide

water

→

yellow solid

収率 91.0%

1-(4-Cyanophenyl)-3-phenyl-2-propen-1-one

収率 91.0%

溶媒

ethanol

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture stirred for 2 hr at room temperature
2. 2
   ろ過The resulting mixture was filtered
3. 3
   その他recrystallized from ethanol

実験手順

4-Acetylbenzonitrile (44al, 1.00 g, 6.9 mmol), sodium hydroxide (0.40 g, 10.0 mmol) and water (20 ml) were combined in ethanol (20 ml) and stirred for 15 min at room temperature. Benzaldehyde (1b, 0.70 ml, 6.9 mmol) was added and the mixture stirred for 2 hr at room temperature. The resulting mixture was filtered and recrystallized from ethanol to give 1.46 g (91%) of a yellow solid: mp 120° C. [expected mp 119-120° C.]; 1H NMR: δ 7.34 (m, 3H), 7.62 (m, 2H), 7.80 (m, 4H), 8.06 (d, 2H, J=8.1 Hz); 13C NMR: δ 115.9, 117.9, 121.1, 128.6, 128.8, 129.0, 131.0, 132.4, 134.3, 141.4, 146.4, 188.9.

出典