反応 #164679

反応方程式

Ethyl 4-chloroacetoacetate

2-methyl-2-propanethiol

triethylamine

→

desired product

4-tert-Butylsulfanyl-3-oxo-butyric acid ethyl ester

溶媒

THF

反応条件

後処理

1. 1
   workup.ADDITIONSilica gel was added
2. 2
   濃縮the mixture was concentrated
3. 3
   ろ過filtered over a plug of silica gel

実験手順

Ethyl 4-chloroacetoacetate (7.5 mL, 51.9 mmol), 2-methyl-2-propanethiol (5.6 mL, 49.7 mmol), triethylamine (10.8 mL, 77.4 mmol), and catalytic tetrabutylammonium bromide were dissolved in THF (250 mL) and stirred at room temperature overnight. Silica gel was added, and the mixture was concentrated and filtered over a plug of silica gel to obtain the desired product (B-1), which was used without further purification.

出典