反応 #164599

反応方程式

4-cyclohexylbenzoic acid

1-ethyl-3-(3-dimethylamino-propyl)carbodiimide

1-hydroxybenzotriazole

diisopropylethylamine

((S)-6-{[(4-methoxybenzyl)-(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)methylamine

→

4-Cyclohexyl-N—((S)-6-{[(4-methoxybenzyl)(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

溶媒

DMF

反応条件

後処理

1. 1
   その他Volatile fractions were removed after 12 hours
2. 2
   その他The residue was purified by preparative HPLC
3. 3
   その他The product was thus obtained with the molecular weight of 594.84 (C28H38N2O3)

実験手順

A mixture of 4-cyclohexylbenzoic acid (45 mg), DMF (1 ml), 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (hydrochloride, 45 mg) and 1-hydroxybenzotriazole (32 mg) was admixed after 5 minutes with diisopropylethylamine (30 mg) and ((S)-6-{[(4-methoxybenzyl)-(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)methylamine (80 mg). Volatile fractions were removed after 12 hours. The residue was purified by preparative HPLC. The product was thus obtained with the molecular weight of 594.84 (C28H38N2O3); MS (ESI) 595 (M+H+).

出典