反応 #164593

反応方程式

sodium cyanoborohydride

4-cyclopropylmethoxy-N—((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

THF

C-(tetrahydropyran-4-yl)methylamine

→

4-Cyclopropylmethoxy-N-methyl-N—((S)-6-{[(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide

溶媒

acetic acid

反応条件

後処理

1. 1
   ろ過The polymer was filtered off with suction
2. 2
   濃縮the filtrate was concentrated
3. 3
   その他The residue was purified by preparative HPLC
4. 4
   その他The product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3)

実験手順

To a mixture of 4-cyclopropylmethoxy-N—((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide (0.20 g), THF (5 ml), C-(tetrahydropyran-4-yl)methylamine (63 mg) and acetic acid (33 mg) was added polymer-bound sodium cyanoborohydride (0.55 mmol), and the suspension was shaken at room temperature for 12 hours. The polymer was filtered off with suction and the filtrate was concentrated. The residue was purified by preparative HPLC. The product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3); MS (ESI): 463.3 (M+H+).

出典