反応 #164525

反応方程式

potassium iodide

2-chloromethyl-8-(2-chloro-5-thiazolyl)methyl-1,4-dioxa-8-azaspiro[4,5]decane

potassium carbonate

5-chloro-2-fluoroaniline

→

N-(5-chloro-2-fluorophenyl)-N-{8-(2-chloro-5-thiazolyl)methyl-1,4-dioxa-8-aza-spiro[4,5]dec-2-yl}methanamine

収率 85.0%

溶媒

water

DMF

反応条件

後処理

1. 1
   workup.ADDITIONThe mixture was poured into ice-
2. 2
   抽出the mass was extracted with ethyl acetate
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   その他to get the dark brick red colored product with yield 85%

実験手順

21 gm (0.065 mole) of 2-chloromethyl-8-(2-chloro-5-thiazolyl)methyl-1,4-dioxa-8-azaspiro[4,5]decane was taken in DMF (300 ml) at 28° C. To this mixture was added 28 gm of potassium carbonate, 10 gm of 5-chloro-2-fluoroaniline and the catalyst potassium iodide. The mass was kept at 140° C. for 20 hrs. The mixture was poured into ice-cooled water and the mass was extracted with ethyl acetate. The solvent was distilled off to get the dark brick red colored product with yield 85%.

出典