反応 #164437

ord-e1b8f4cebdf942f3a50951d8c18284b7

反応方程式

OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O
sucrose
O=C(O)CC(O)(CC(=O)O)C(=O)O
Citric acid
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
Aspartame
CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21.O=C(O)C(=O)O
Escitalopram Oxalate
→
CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21
Escitalopram

反応物

—
sodium alginate
OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O
sucrose
O=C(O)CC(O)(CC(=O)O)C(=O)O
Citric acid
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
Aspartame
CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21.O=C(O)C(=O)O
Escitalopram Oxalate

試薬

なし

溶媒

OCC(O)CO
glycerol
O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.DISSOLUTIONdissolved at 60° C
  2. 2
    workup.DISSOLUTIONdissolved
  3. 3
    その他dried

実験手順

The composition of the formulation and the amounts of the ingredients are shown in the table below. Citric acid was dissolved in 200 ml of distilled water and then sodium alginate (Protanal LF10/60, FMC Biopolymer), glycerol and sucrose were added and dissolved at 60° C. The obtained solution was cooled to ambient temperature and, then, Aspartame, Escitalopram Oxalate and Fantasy flavor were added and dissolved therein. The resulting solution was cast onto casting mold having casting area of 1,150 cm2 and dried according to Example 3.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08840935B2uspto-grants-2014_09