反応 #1642

反応方程式

(S)-4-{2-[2-hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)propylamino]ethyl}phenoxymethyl-(3-benzyloxypropyl)phosphinic acid, n-butyl ester

hydrochloric acid

→

title compound

(S)-4-{2-[2-Hydroxy-3-(4-hydroxy-3-hydroxymethylphenoxy)propylamino]ethyl}phenoxymethyl-(3-benzyloxypropyl)phosphinic acid

反応条件

後処理

1. 1
   洗浄eluting with water-methanol (30%)
2. 2
   その他freeze drying of the resultant foam

実験手順

The title compound was prepared from (S)-4-{2-[2-hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)propylamino]ethyl}phenoxymethyl-(3-benzyloxypropyl)phosphinic acid, n-butyl ester according to a modification of the procedure described in Example 5. Acidification to pH 3.5 with 1M hydrochloric acid followed by C18 reverse phase chromatography, eluting with water-methanol (30%) and freeze drying of the resultant foam gave the title compound as a solid.

出典