反応 #164172

反応方程式

Ethyl 2-bromo-2-phenylacetate

3-(methylthio)aniline

DIPEA

→

oil

収率 79.0%

(3-methylsulfanyl-phenylamino)-phenyl-acetic acid ethyl ester

収率 79.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他Acetonitrile is evaporated
2. 2
   その他the crude residue is purified by flash chromatography (petroleum ether/EtOAc=85/15)

実験手順

Ethyl 2-bromo-2-phenylacetate (0.22 mL, 1.23 mmol), 3-(methylthio)aniline (0.22 mL, 1.85 mmol), and DIPEA (0.32 mL, 1.85 mmol) are dissolved in acetonitrile (3 mL) and heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile is evaporated and the crude residue is purified by flash chromatography (petroleum ether/EtOAc=85/15) to obtain intermediate I98 as a colorless oil (292 mg, 79% yield).

出典