反応 #164027

反応方程式

Ammonium hydroxide

D-tert-leucine

→

DL-tert-leucine

収率 92.0%

溶媒

acetone

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他Autoclave was closed
3. 3
   温度After cooling the solution
4. 4
   濃縮concentrated under vacuum at 55° C
5. 5
   その他The solid residue obtained
6. 6
   ろ過filtered
7. 7
   その他dried

実験手順

Ammonium hydroxide (50 mL, 30%) solution was placed in an autoclave and D-tert-leucine (5 g) was added. Autoclave was closed and the contents were heated to 85° C. under stirring for 12 hours. After cooling the solution was transferred and concentrated under vacuum at 55° C. The solid residue obtained was stirred with acetone (20 mL), filtered and dried to obtain DL-tert-leucine (4.6 g, 92% yield, L-isomer: 42%, D-isomer: 58%)

出典