反応 #163955

反応方程式

Methyl chloroacetate

1-(trimethylsilyl)-1H-imidazole

→

9

収率 99.7%

1,3-Bis(2-methoxy-2-oxoethyl)-1H-imidazol-3-ium chloride

収率 99.7%

反応条件

後処理

1. 1
   温度The mixture was cooled to room temperature
2. 2
   洗浄washed with Et2O (3×500 mL)
3. 3
   その他dried in vacuo

実験手順

Methyl chloroacetate (2; 29.8 mL, 338.6 mmol, 2.0 eq) was added drop-wise to 1-(trimethylsilyl)-1H-imidazole (8; 25.0 mL, 169.3 mmol). The mixture was heated at 60° C. for 24 hours. The mixture was cooled to room temperature, washed with Et2O (3×500 mL) and dried in vacuo yielding 9 (41.97 g, 168.8 mmol, 99.7%) as a white solid.

出典