反応 #1637

反応方程式

(S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

benzyl bromide

sodium carbonate

→

title compound

(S)-N-Benzyl-1(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

溶媒

dimethylformamide

反応条件

後処理

1. 1
   ろ過The mixture was filtered
2. 2
   洗浄the residue was washed with ethyl acetate
3. 3
   洗浄washed with water and brine
4. 4
   その他dried
5. 5
   その他evaporated
6. 6
   その他Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane)

実験手順

A solution of (S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol (1.9 g, 4.8 mMol) and benzyl bromide (0.57 ml, 4.8 mMol) in dimethylformamide (10 ml) containing sodium carbonate (770 mg, 7.2 mMol) was stirred at room temperature for 18 hours. The mixture was filtered and the residue was washed with ethyl acetate. The filtrates were combined, washed with water and brine, dried and evaporated. Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane) gave the title compound.

出典