反応 #163254

反応方程式

[4-(4-acetyl-phenyl)-cyclohexyl]-acetic acid ethyl ester

glyoxylic acid monohydrate

Hydrazine

ammonium hydroxide

→

title compound

{4-[4-(6-Oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-cyclohexyl}-acetic acid ethyl ester

溶媒

water

acetic acid

反応条件

後処理

1. 1
   温度The mixture was then cooled to 40° C.
2. 2
   温度the reaction was then heated to 95° C. for 2 hr
3. 3
   温度Upon cooling to room temperature
4. 4
   ろ過a solid precipitate was filtered off

実験手順

To a solution of [4-(4-acetyl-phenyl)-cyclohexyl]-acetic acid ethyl ester (17 g, 59 mmol, 1.0 equiv) in 100 Ml glacial acetic acid was added glyoxylic acid monohydrate (5.4 g, 59 mmol, 1.0 equiv) as a solid. The solution was heated to 100° C. for 2 h. The mixture was then cooled to 40° C., then 75 Ml water was added followed by 120 Ml of a 28% ammonium hydroxide solution until the Ph was measured to be 8. Hydrazine (2.0 Ml, 65 mmol, 1.1 equiv) was then added via syringe, and the reaction was then heated to 95° C. for 2 hr. Upon cooling to room temperature, a solid precipitate was filtered off to afford the title compound in addition to the uneliminated product {4-[4-(5-hydroxy-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-cyclohexyl}-acetic acid ethyl ester. This mixture was taken into the next step without further purification. (M+H)+341.2.

出典