反応 #162961

反応方程式

KBr

3-(4-amino-phenyl)-isoxazol-5-carboxylic acid ethyl ester

cyclohexyl isocyanate

3-[4-(3-phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

→

title compound

収率 75.0%

3-[4-(3-cyclohexyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

収率 75.0%

反応条件

後処理

1. 1
   その他was obtained in 75% yield

実験手順

The title compound was prepared from 3-(4-amino-phenyl)-isoxazol-5-carboxylic acid ethyl ester and cyclohexyl isocyanate by same procedure as set forth for the preparation of 3-[4-(3-phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester and was obtained in 75% yield. Mass (ES+), 358 (M++1); IR (KBr): 3304, 2928, 2852, 1731, 1634, 1570 (br); 1H NMR (DMSO-d6) δ: 1.33 (t, 3H), 1.14-1.81 (4×m, 10H), 3.45 (br, 1H), 4.37 (q, 2H), 6.18 (d, 1H), 7.50 (d, 2H), 7.60 (s, 1H), 7.79 (s, 1H), 7.8.1 (d, 2H), 8.59 (s, 1H).

出典