反応 #162950

反応方程式

3-(3-amino-phenyl)-isoxazole-5-carboxylic acid ethyl ester

2-chloro-6-fluoro-benzothiazole

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title compound

3-[3-(6-Fluoro-benzothiazol-2-ylamino)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

反応条件

後処理

1. 1
   その他The title compound was prepared
2. 2
   その他The solid was separated
3. 3
   ろ過filtered
4. 4
   洗浄washed with EtOH
5. 5
   その他dried

実験手順

The title compound was prepared by reacting 3-(3-amino-phenyl)-isoxazole-5-carboxylic acid ethyl ester with 2-chloro-6-fluoro-benzothiazole as described in Example 1, step 3. The solid was separated, filtered, washed with EtOH and dried to give the title compound in 90% yield. Mass (ES+), 384 (M++1); IR (KBr): 3423 (br), 2666 (br), 1723, 1629, 1598; 1H NMR (DMSO-d6) δ: 1.33 (t, 3H), 4.39 (q, 2H), 7.15 (m, 1H), 7.52 (m, 1H), 7.61 (m, 2H), 7.82 (s, 1H), 7.74 (m, 1H), 7.97 (m, 1H), 8.34 (m, 1H), 10.97 (br, 1H).

出典