反応 #162570

反応方程式

2-(1-(6-fluoro-3-(pyridin-2-yl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione

ethanol

hydrazine, monohydrate

→

1-(6-fluoro-3-(pyridin-2-yl)quinoxalin-2-yl)ethanamine

収率 97.3%

反応条件

後処理

1. 1
   workup.WAITThe hetereogeneous reaction mixture went into solution after 15 min
2. 2
   温度After 1 h the mixture was cooled to rt
3. 3
   ろ過filtered
4. 4
   洗浄washed with EtOAc (3×250 mL portions)
5. 5
   濃縮The filtrate was concentrated under reduced pressure
6. 6
   workup.DISSOLUTIONThe residue was redissolved in EtOAc (600 mL)
7. 7
   その他The organic layer was separated
8. 8
   抽出the aqueous layer was extracted with EtOAc (100 mL×3)
9. 9
   乾燥The combined organic layer were dried over MgSO4
10. 10
    ろ過filtered
11. 11
    濃縮concentrated under reduced pressure

実験手順

To a heterogeneous mixture of 2-(1-(6-fluoro-3-(pyridin-2-yl)quinoxalin-2-yl)ethyl)isoindoline-1,3-dione (47.26 g, 118.6 mmol) in ethanol (768.3 ml, 118.6 mmol) was added hydrazine, monohydrate (28.77 ml, 593.1 mmol) and the mixture was stirred at 95° C. for 1 h. The hetereogeneous reaction mixture went into solution after 15 min, but voluminous white ppt followed. After 1 h the mixture was cooled to rt. The precipitate was broken up with a spatula, filtered and washed with EtOAc (3×250 mL portions). The filtrate was concentrated under reduced pressure. The residue was redissolved in EtOAc (600 mL) and water (300 mL). The organic layer was separated and the aqueous layer was extracted with EtOAc (100 mL×3). The combined organic layer were dried over MgSO4, filtered, and concentrated under reduced pressure to give 1-(6-fluoro-3-(pyridin-2-yl)quinoxalin-2-yl)ethanamine (30.95 g, 97.25% yield) as a brown solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.75 (dq, J=4.7, 0.9 Hz, 1H), 8.20 (dd, J=9.0, 5.9 Hz, 1H), 7.98-8.11 (m, 2H), 7.91 (dd, J=9.4, 2.7 Hz, 1H), 7.78-7.86 (m, 1H), 7.56-7.61 (m, 1H), 4.66 (q, J=6.7 Hz, 1H), 2.08 (br. S, 2H), 1.35 (d, J=6.7 Hz, 3H). Mass Spectrum (ESI) m/e=269.0 (M+1). [Chiral HPLC] (Chiralpak AD-H column, 0.46×250 mm, 5 um) using 10% isocratic of isopropanol in hexane as eluent: two peaks at 9.350 min and at 10.678 min at 254 nm, (Chiralpak OD-H column, 0.46×250 mm, 5 um) using 10% isocratic of isopropanol in hexane as eluent: two peaks at 9.69 min and at 11.22 min at 254 nm.

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