反応 #162266

反応方程式

carboxylic acid

6-Methacryloyloxy-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-7-carboxylic Acid

oxalyl chloride

→

7-Chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-6-yl Methacrylate

溶媒

toluene

反応条件

後処理

1. 1
   その他obtained in Synthesis Example 1-1-2
2. 2
   その他at 80° C
3. 3
   その他toluene was removed by distillation under reduced pressure
4. 4
   その他to obtain the intended product

実験手順

Suspended into 135 mL of toluene was 18.0 g of the carboxylic acid (26) obtained in Synthesis Example 1-1-2, and then into the resulting suspension was gradually added 10.3 g of oxalyl chloride at 80° C. After this mixture was stirred for 4 hours, toluene was removed by distillation under reduced pressure to obtain the intended product. The obtained acid chloride was used in the next reaction without further purification.

出典