反応 #161762

反応方程式

2-chloroisonicotinic acid

5,6-difluoro-2,3-dihydro-1 H-indole

TBTU

→

(2-chloro-pyridin-4-yl)-(5,6-difluoro-2,3-dihydro-indol-1-yl)-methanone

溶媒

DMF

反応条件

後処理

1. 1
   その他The reaction mixture was purified by HPLC
2. 2
   その他evaporated down

実験手順

0.35 g (2.2 mmol) 2-chloroisonicotinic acid, 0.34 g (2.2 mmol) 5,6-difluoro-2,3-dihydro-1 H-indole, 0.70 mL (5.0 mmol) TEA and 10 mL DMF were mixed with 0.77 g (2.4 mmol) TBTU and stirred for 2 h at RT. The reaction mixture was purified by HPLC. The product fractions were combined and evaporated down.

出典