反応 #1616996

反応方程式

phenoxyacridine

4-3

(2-Aminoethyl)glycine

→

(2-(Acridin-9-ylamino)ethyl)glycine

(2-Aminoethyl)glycine

溶媒

MeOH

反応条件

後処理

1. 1
   温度was refluxed for 36 h
2. 2
   その他The yellow solid that precipitated during the reaction
3. 3
   ろ過was collected by filtration
4. 4
   洗浄washed with ethanol and ether
5. 5
   その他dried in a vacuum

実験手順

2-((2-Aminoethyl)glycine (4-3) was synthesized following the method reported by Gilon. 2-((2-(Acridin-9-ylamino)ethyl)glycine was synthesized as follows. A mixture of phenoxyacridine (1.35 g, 0.005 mol) and 4-3 (0.65 g, 0.0055 mol) in 20 mL of dry MeOH was refluxed for 36 h. The yellow solid that precipitated during the reaction was collected by filtration, and washed with ethanol and ether, then dried in a vacuum, affording 2.2 g of the product as a yellow solid (Yield: 75%). The structural identity of this compound was confirmed by ESI-MS rather than by NMR spectroscopy due to limited solubility of the compound in common NMR solvents. ESI-MS, +ve mode, m/z [(M+H]+=296.

出典