反応 #161691

反応方程式

5-fluoro-2,3-dihydro-1H-indole

4-chloropyridine-2-carboxylic acid

triethylamine

TBTU

→

(4-chloropyridin-2-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone

溶媒

DMF

反応条件

後処理

1. 1
   その他Purification
2. 2
   その他evaporated down i

実験手順

174 mg (1.27 mmol) 5-fluoro-2,3-dihydro-1H-indole were added to 200.0 mg (1.27 mmol) 4-chloropyridine-2-carboxylic acid, 351 μL (2.50 mmol) triethylamine and 434.0 mg (1.35 mmol) TBTU in 3 mL DMF. The reaction mixture was stirred overnight at RT. Purification was carried out by preparative HPLC. The product fractions were combined and evaporated down i. vac.

出典