反応 #1615

反応方程式

3-benzyloxyphenol

potassium carbonate

(S)-Glycidyl-3-nitrobenzenesulphonate

→

title compound

(S)-Glycidyl-3-benzyloxyphenol

溶媒

acetone

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 15 mins
3. 3
   温度the reaction mixture was heated
4. 4
   温度under reflux for 23 hours
5. 5
   温度After cooling the reaction mixture
6. 6
   ろ過was filtered
7. 7
   その他the solvent was evaporated
8. 8
   その他The residue was partitioned between ethyl acetate and water
9. 9
   洗浄washed with water and brine
10. 10
    その他dried
11. 11
    その他evaporated

実験手順

A mixture of 3-benzyloxyphenol (900 mg, 4.5 mMol) and potassium carbonate (1.87 g, 13.5 mMol) in acetone (45 ml) was heated under reflux for 15 mins. (S)-Glycidyl-3-nitrobenzenesulphonate (1.0 g, 4.5 mMol) was added and the reaction mixture was heated under reflux for 23 hours. After cooling the reaction mixture was filtered and the solvent was evaporated. The residue was partitioned between ethyl acetate and water. The organic fractions were combined, washed with water and brine, dried and evaporated to give the title compound as an oil.

出典