反応 #1614830

ord-d5c273cad9c4439f94bde23bc6e97369

反応方程式

Cl.Clc1cccc(Cl)c1NC1=NCCN1
clonidine hydrochloride
O=P([O-])([O-])O.[Ca+2]
calcium phosphate dibasic
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
→
Clc1cccc(Cl)c1NC1=NCCN1
Clonidine

反応物

—
hydroxypropyl methyl cellulose
Cl.Clc1cccc(Cl)c1NC1=NCCN1
clonidine hydrochloride
O=P([O-])([O-])O.[Ca+2]
calcium phosphate dibasic
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
—
cellulose

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Basically 0.1 mg (base equivalent) of clonidine hydrochloride was blended with 13 mg of calcium phosphate dibasic, with 15 mg of microcrystalline cellulose, with 40 mg of hydroxypropyl methyl cellulose, 1 mg of colloidal silica and 0.9 mg of magnesium stearate.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09089559B2uspto-grants-2015_07