反応 #161409

反応方程式

2-(2-cyclopropylaminoanilin-5-yl)benzoxazole

1,1,1-trimethoxyethane

→

imidazole

収率 51.6%

5-(benzoxazol-2-yl)-2-methyl-1-cyclopropylbenzimidazole

収率 51.6%

溶媒

methanol

反応条件

後処理

1. 1
   濃縮this was concentrated
2. 2
   その他the residue obtained
3. 3
   その他was purified by silica gel column chromatography

実験手順

To a methanol (5 mL) solution of 2-(2-cyclopropylaminoanilin-5-yl)benzoxazole (see Working Example 53-1) (140 mg, 0.425 mmol) was added 1,1,1-trimethoxyethane (75 mg, 0.624 mmol), and this was stirred at room temperature for 6 hours. After the reaction was complete, this was concentrated, and the residue obtained was purified by silica gel column chromatography to yield the imidazole (63.5 mg, 42% yield).

出典