反応 #161128

反応方程式

1-benzenesulfonyl-5-ethyl-2,3-dihydro-1H-indole

NaOH

→

5-ethyl-2,3-dihydro-1H-indole

収率 34.0%

溶媒

HBr

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 6 h
3. 3
   抽出extracted with ethyl acetate
4. 4
   洗浄The organic layer was washed with brine
5. 5
   乾燥dried over Na2SO4
6. 6
   濃縮concentrated under reduced pressure
7. 7
   その他The residue was purified by column chromatography on silica gel

実験手順

A mixture of 1-benzenesulfonyl-5-ethyl-2,3-dihydro-1H-indole (15 g, 0.05 mol) in HBr (48%, 162 mL) was heated at reflux for 6 h. The mixture was basified with sat. NaOH solution to pH 9 and extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to give 5-ethyl-2,3-dihydro-1H-indole (2.5 g, 32%).

出典