反応 #161099

反応方程式

o-tolylamine

Et3N

2,2-dimethyl-propionyl chloride

→

2,2-dimethyl-N-o-tolyl-propionamide

収率 92.0%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   洗浄washed with aq. HCl (5%, 80 mL), saturated NaHCO3 solution and brine
2. 2
   乾燥dried over Na2SO4
3. 3
   濃縮concentrated under vacuum

実験手順

To a solution of o-tolylamine (21.4 g, 0.20 mol) and Et3N (22.3 g, 0.22 mol) in CH2Cl2 was added 2,2-dimethyl-propionyl chloride (25.3 g, 0.21 mol) at 10° C. The mixture was stirred overnight at room temperature, washed with aq. HCl (5%, 80 mL), saturated NaHCO3 solution and brine, dried over Na2SO4 and concentrated under vacuum to give 2,2-dimethyl-N-o-tolyl-propionamide (35.0 g, 92%).

出典