反応 #160971

反応方程式

6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamide

4-fluoro-5-(tributylstannyl)-1H-pyrazole

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title compound

6-Chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-(4-fluoro-1H-pyrazol-5-yl)nicotinamide

反応条件

後処理

1. 1
   その他to afford an off-white powder

実験手順

The title compound was prepared in an analogous fashion to that described in Stage 13.1 using 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamide (Stage 25.2) and 4-fluoro-5-(tributylstannyl)-1H-pyrazole to afford an off-white powder. HPLC (Condition 4) tR=5.69 min, UPLC-MS (Condition 3) tR=1.09 min, m/z=415 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm.

出典