反応 #160950

ord-1d2172036dcf403088242e3e8f1fe91a

反応方程式

O=C(Nc1ccc(C(F)(F)C(F)(F)F)cc1)c1cnc(Cl)c(Br)c1
5-bromo-6-chloro-N-(4-(perfluoroethyl)phenyl)nicotinamide
O[C@@H]1CCNC1
(R)-pyrrolidin-3-ol
→
O=C(Nc1ccc(C(F)(F)C(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1
title compound
O=C(Nc1ccc(C(F)(F)C(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(Br)c1
(R)-5-Bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(perfluoroethyl)phenyl)nicotinamide

反応物

O=C(Nc1ccc(C(F)(F)C(F)(F)F)cc1)c1cnc(Cl)c(Br)c1
5-bromo-6-chloro-N-(4-(perfluoroethyl)phenyl)nicotinamide
O[C@@H]1CCNC1
(R)-pyrrolidin-3-ol

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他to afford an off-white crystalline solid

実験手順

The title compound was prepared in an analogous fashion to that described in Stage 9.2 using 5-bromo-6-chloro-N-(4-(perfluoroethyl)phenyl)nicotinamide (Stage 16.3) and (R)-pyrrolidin-3-ol to afford an off-white crystalline solid. HPLC (Condition 4) tR=5.96 min, UPLC-MS (Condition 3) tR=1.20 min, m/z=480.2 [M+H]+.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08829195B2uspto-grants-2014_09