反応 #160746

反応方程式

benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate

→

diethyl 4-chloropiperidin-3-ylphosphoramidate

収率 92.0%

溶媒

MeOH

反応条件

後処理

1. 1
   ろ過The solution was filtered
2. 2
   濃縮concentrated

実験手順

To a solution of benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate (1.0 equiv.) in degassed MeOH was added Pd/C (10% by weight) and the reaction was stirred under a hydrogen atmosphere for 1 h. The solution was filtered, then concentrated to yield diethyl 4-chloropiperidin-3-ylphosphoramidate in 92% yield. LCMS (m/z): 271.0 (MH+).

出典