反応 #1606

反応方程式

ammonium chloride

2-(4-chlorophenyl)dimethylaminopropenal

urea

HCl

→

5-(4-chlorophenyl)-2-pyrimidinone

収率 29.7%

溶媒

ethanol

water

反応条件

後処理

1. 1
   温度was refluxed for 4 hours
2. 2
   workup.ADDITIONwas added until the pH was 7
3. 3
   ろ過The resulting yellow solid was filtered off
4. 4
   その他dried

実験手順

A mixture of 2-(4-chlorophenyl)dimethylaminopropenal (Example 145a) (5.13 g), urea (2.4 g), concentrated HCl (10 ml), water (4 ml) and ethanol (150 ml) was refluxed for 4 hours. After cooling to room temperature concentrated ammonium chloride was added until the pH was 7. The resulting yellow solid was filtered off and dried yielding 1.5 g of 5-(4-chlorophenyl)-2-pyrimidinone.

出典