反応 #1605828

反応方程式

4-(Hydroxyethyl)phenol

potassium carbonate

1,2-dibromoethane

→

2-[4-(2-bromoethoxy)phenyl]-1-ethanol

収率 15.3%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出the reaction solution was extracted with ethyl acetate
2. 2
   洗浄The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他The residue was purified by flash column chromatography

実験手順

4-(Hydroxyethyl)phenol (2.7 g, 20.0 mmol) was dissolved in N,N-dimethylformamide (50 mL) and thereto were added potassium carbonate (6.90 g, 50.0 mmol) and 1,2-dibromoethane (15.03 g, 80.0 mmol). After stirring at 80° C. for 6 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain 2-[4-(2-bromoethoxy)phenyl]-1-ethanol (750.0 mg).

出典