反応 #1605821

反応方程式

5-Acetyl-8-hydroxy-1H-quinolin-2-one

potassium carbonate

4-methoxybenzyl chloride

→

5-acetyl-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one

収率 53.8%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   workup.ADDITIONTo the reaction mixture was added
2. 2
   その他purified water (0.5 L)
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature overnight
4. 4
   ろ過The precipitate was collected by filtration
5. 5
   洗浄washed with purified water
6. 6
   その他dried under reduced pressure

実験手順

5-Acetyl-8-hydroxy-1H-quinolin-2-one (29.5 g, 0.15 mol) was suspended in N,N-dimethylformamide (145 mL), potassium carbonate (22.2 g, 0.16 mol) and successively 4-methoxybenzyl chloride (22.7 g, 0.15 mol) were added thereto, and the mixture was stirred at 90° C. overnight. To the reaction mixture was added purified water (0.5 L) and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with purified water, dried under reduced pressure to obtain 5-acetyl-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one (26.1 g).

出典