反応 #1605820

反応方程式

3-Nitro-4-phenylphenol

tert-butyl 2-bromoacetate

→

tert-butyl 2-(3-nitro-4-phenylphenoxy)acetate

収率 112.3%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出the reaction solution was extracted with ethyl acetate
2. 2
   洗浄The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他The residue was purified by flash column chromatography

実験手順

3-Nitro-4-phenylphenol (215 mg, 1.0 mmol) was dissolved in N,N-dimethylformamide (5 mL) and tert-butyl 2-bromoacetate (292 mg, 1.5 mmol) was added thereto. After stirring at 80° C. for 18 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain tert-butyl 2-(3-nitro-4-phenylphenoxy)acetate (370 mg).

出典