反応 #1605819

反応方程式

4-(Hydroxymethyl)phenol

potassium carbonate

4-bromo-1-butene

→

[4-(2-propenoyloxy)phenyl]methanol

収率 30.0%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出the reaction solution was extracted with ethyl acetate
2. 2
   洗浄The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他The residue was purified by flash column chromatography

実験手順

4-(Hydroxymethyl)phenol (620 mg, 5.0 mmol) was dissolved in N,N-dimethylformamide (25 ml) and potassium carbonate (1.38 g, 10.0 mmol) and 4-bromo-1-butene (1.08 g, 8.0 mmol) were added thereto. After stirring at 70° C. for 4 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain [4-(2-propenoyloxy)phenyl]methanol (267 mg).

出典