反応 #1605817

反応方程式

3-Nitro-4-phenylphenol

8-bromo-1-octanol

→

8-(3-nitro-4-phenylphenoxy)octan-1-ol

収率 89.5%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出the reaction solution was extracted with ethyl acetate
2. 2
   洗浄The organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他The residue was purified by flash column chromatography

実験手順

3-Nitro-4-phenylphenol (860 mg, 4.0 mmol) was dissolved in N,N-dimethylformamide (40 mL), followed by addition of 8-bromo-1-octanol (1.86 g, 6.0 mmol). After stirring at 50° C. for 5 hours, the reaction solution was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain 8-(3-nitro-4-phenylphenoxy)octan-1-ol (1.23 g).

出典