反応 #1605812

反応方程式

2-Phenyl-N-acetylaniline

hydrogen bromide

→

2-phenyl-4-bromo-N-acetylaniline

収率 91.3%

溶媒

carbon tetrachloride

acetic acid

反応条件

後処理

1. 1
   濃縮The solution was concentrated under reduced pressure, to the residue
2. 2
   workup.ADDITIONwas added water (20 mL) and subsequently ethanol (30 mL)
3. 3
   workup.STIRRINGthe mixture was stirred under ice bath for 1 hour
4. 4
   ろ過The precipitate was collected by filtration
5. 5
   洗浄washed with ethanol/water (=1:1)
6. 6
   その他dried under reduced pressure

実験手順

2-Phenyl-N-acetylaniline (6.21 g, 29.40 mmol) was dissolved in acetic acid (70 mL). Thereto was dropwise added under ice bath a separately prepared solution of hydrogen bromide (6.14 g, 38.42 mmol) dissolved in carbon tetrachloride (19.21 mL) and the mixture was stirred at room temperature overnight. The solution was concentrated under reduced pressure, to the residue was added water (20 mL) and subsequently ethanol (30 mL), and the mixture was stirred under ice bath for 1 hour. The precipitate was collected by filtration, washed with ethanol/water (=1:1), dried under reduced pressure to obtain 2-phenyl-4-bromo-N-acetylaniline (7.79 g).

出典