反応 #1605810

反応方程式

2-Methyl-4-nitrobenzoic acid

→

4-amino-2-methylbenzoic acid

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The reaction solution was filtered through celite
2. 2
   濃縮the filtrate was concentrated under reduced pressure

実験手順

2-Methyl-4-nitrobenzoic acid (741 g, 5 mmol) was dissolved in methanol (20 mL), 10% palladium-carbon (100 mg) was added, and the mixture was stirred under a hydrogen atmosphere at room temperature for 16 hours. The reaction solution was filtered through celite and, thereafter, the filtrate was concentrated under reduced pressure to obtain 4-amino-2-methylbenzoic acid as a crude material. In accordance with Reference Example 23 and Reference Example 14, from 4-amino-2-methylbenzoic acid obtained, there was obtained 4-[(tert-butyldimethylsilanoyloxy)methyl]-3-methylaniline (0.33 g).

出典