反応 #1605808

反応方程式

4-Hydroxypiperidine

potassium carbonate

(2-bromoethoxy)benzene

→

1-(2-phenoxyethyl)piperidin-4-ol

収率 76.6%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出The reaction solution was extracted with ethyl acetate
2. 2
   洗浄the organic layer was washed with a saturated aqueous solution of sodium chloride
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他The residue was purified by flash column chromatography

実験手順

4-Hydroxypiperidine (5.06 g, 50 mmol) was dissolved in N,N-dimethylformamide (200 mL), potassium carbonate (13.8 g, 100 mmol) and (2-bromoethoxy)benzene (12.9 g, 60 mmol) were added thereto, and the mixture was stirred at 70° C. for 18 hours. The reaction solution was extracted with ethyl acetate and the organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain 1-(2-phenoxyethyl)piperidin-4-ol (8.48 g).

出典