反応 #1605807

反応方程式

Benzyl 4-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]butyrate

→

4-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]butyric acid

溶媒

ethyl acetate

反応条件

後処理

1. 1
   workup.WAITat 50° C. for 6 hours
2. 2
   ろ過After filtering the reaction solution through celite
3. 3
   濃縮the filtrate was concentrated under reduced pressure

実験手順

Benzyl 4-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]butyrate (25.8 g, 5.30 mmol) was dissolved in ethyl acetate (250 mL), 10% palladium hydroxide-carbon (5 g) was added thereto, and the mixture was stirred under a hydrogen atmosphere at room temperature for 3 days and, thereafter, at 50° C. for 6 hours. After filtering the reaction solution through celite, the filtrate was concentrated under reduced pressure to obtain 4-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]butyric acid (21.3 g).

出典